Raw datasets - Circadian organization of lipid landscape is perturbed in type 2 diabetic patients

Lipid homeostasis in humans follows a diurnal pattern in muscle and pancreatic islets, altered upon metabolic dysregulation. We employ tandem and liquid-chromatography mass spectrometry to investigate daily regulation of lipid metabolism in subcutaneous white adipose tissue (SAT) and serum of type 2 diabetic (T2D) and non-diabetic (ND) human volunteers (n = 12). Around 8% of z440 lipid metabolites exhibit diurnal rhythmicity in serum and SAT from ND and T2D subjects. The spectrum of rhythmic lipids differs between ND and T2D individuals, with the most substantial changes observed early morning, as confirmed by lipidomics in an independent cohort of ND and T2D subjects (n = 32) conducted at a single morning time point. Strikingly, metabolites identified as daily rhythmic in both serum and SAT from T2D subjects exhibit phase differences. Our study reveals massive temporal and tissue-specific alterations of human lipid homeostasis in T2D, providing essential clues for the development of lipid biomarkers in a temporal manner.

    Organizational unit
    University of Geneva, Dibner Lab
    Referenced by the following DOI
    • 10.1016/j.xcrm.2023.101299
    Creative Commons Attribution 4.0 International
    lipids, circadian organization, type 2 diabetes
Publication date04/05/2024
Retention date04/03/2034
accessLevelPublicAccess levelPublic
licenseContract on the use of data
  • Sinturel, Flore
  • Chera, Simona
  • Brulhart-Meynet, Marie-Claude
  • Paz Montoya, Jonathan
  • Stenvers, Dirk Jan
  • Bisschop, Peter H.
  • Kalsbeek, Andries
  • Guessous, Idris
  • R. Jornayvaz, Francois
  • Philippe, Jacques
  • Brown, Steven A.
  • D’Angelo, Giovanni
  • Riezman, Howard
  • Dibner, Charna orcid
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