Chimeric liver transplantation reveals interspecific graft remodelling

Dataset corresponding to the publication in Journal of Hepatology 2018 Graziano Oldani ∙ Andrea Peloso ∙ Sandrine Vijgen ∙ Elizabeth M. Wilson ∙ Florence Slits ∙ Quentin Gex ∙ Philippe Morel ∙ Vaihere Delaune ∙ Lorenzo A. Orci ∙ Tomoyuki Yamaguchi ∙ Toshihiro Kobayashi ∙ Laura Rubbia-Brandt ∙ Hiromitsu Nakauchi ∙ Stéphanie Lacotte ∙ Christian Toso Chimeric animals are composed of cells from different species. Chimeric animals carrying human tissue have the potential to increase the availability of transplantable organs. We transplanted rat-to-mouse liver grafts into newly weaned rats. The chimeric grafts underwent post-transplant remodelling with rat hepatocytes replacing all mouse hepatocytes within 56 days. In addition, we observed the post-transplant development of diffuse mature rat bile ducts through the transformation of hepatocytes, and patchy areas of portal endothelium originating from the host. These data demonstrate the efficacy of transplanting rat-to-mouse chimeric livers into rats, with a high potential for post-transplant graft remodelling.

Organizational unit: Transplantation and Hepatology Laboratory

Type: Dataset

DOI: 10.26037/yareta:mthw5jev2remhba42p4ubeoa2q

Identical to the following DOI

License: Creative Commons Attribution 4.0 International

Keywords: Transplantation, chimerism, xenotransplantation

Publication date

14/10/2025

Retention date12/10/2035

Access levelPublic

SensitivityBlue

Contract on the use of data

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Contributors

TOSO, Christian

Lacotte, Stéphanie

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640 Files (120.4 GB)

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Graziano Oldani ∙ Andrea Peloso ∙ Sandrine Vijgen ∙ Elizabeth M. Wilson ∙ Florence Slits ∙ Quentin Gex ∙ Philippe Morel ∙ Vaihere Delaune ∙ Lorenzo A. Orci ∙ Tomoyuki Yamaguchi ∙ Toshihiro Kobayashi ∙ Laura Rubbia-Brandt ∙ Hiromitsu Nakauchi ∙ Stéphanie Lacotte ∙ Christian Toso

Chimeric animals are composed of cells from different species. Chimeric animals carrying human tissue have the potential to increase the availability of transplantable organs. We transplanted rat-to-mouse liver grafts into newly weaned rats. The chimeric grafts underwent post-transplant remodelling with rat hepatocytes replacing all mouse hepatocytes within 56 days. In addition, we observed the post-transplant development of diffuse mature rat bile ducts through the transformation of hepatocytes, and patchy areas of portal endothelium originating from the host. These data demonstrate the efficacy of transplanting rat-to-mouse chimeric livers into rats, with a high potential for post-transplant graft remodelling.</datacite:description>
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