Psychotic experiences in daily-life in adolescents and young adults with 22q11.2 deletion syndrome: an Ecological Momentary Assessment study

Objectives: 22q11.2 deletion syndrome (22q11DS) is a genetic condition associated with a markedly increased risk for psychosis. Psychotic experiences (PE) are classically evaluated by clinical interviews that give little information about the fluctuation of these symptoms in daily-life. Therefore, the current study aims to investigate these phenomena using the Ecological Momentary Assessment (EMA), a structured diary technique that collects real-life measures in the everyday-life context, and to examine how these manifestations relate to a goal standard semi-structured assessment of PE. Method: Eighty-six adolescents and young adults with 22q11DS as well as healthy controls (HC) aged 12-27 were recruited. All participants completed a 6-day ESM protocol assessing momentary psychotic experiences as well as their current mood (measured by positive and negative affects). The presence of (attenuated) psychotic symptoms was assessed in the 22q11DS group with a clinical interview (SIPS). Results: Our main findings indicate that participants with 22q11DS reported more intense and more frequent momentary PE than HC and similar associations between affects (both PA and NA) and momentary PE. In participants with 22q11DS, more intense and more frequent momentary PE measured by EMA were associated with the severity of SIPS positive symptoms. Finally, participants with 22q11DS reporting at least attenuated positive symptoms of psychosis on the SIPS had more frequent and more intense momentary PE than participants with 22q11DS without psychotic symptoms. Conclusions: Altogether, this study highlights the validity of EMA to assess PE and broadens previous findings about mood and PE associations.

    Organizational unit
    Creative Commons Attribution 4.0 International
Publication date01/04/2021
Retention date30/03/2031
accessLevelPublicAccess levelPublic
duaNoneContract on the use of data
  • Feller, Clémence
  • Ilen, Laura
  • Eliez, Stéphan
  • Schneider, Maude
  • Quality (0 Reviews)
  • Usefulness (0 Reviews)

Datacite metadata

Packages information

Similar archives

Increased affective reactivity to daily social stressors is associated with more severe psychotic symptoms in youths with 22q11.2 deletion syndrome
2023 accessLevelPublic Public 858.4 KB
Loneliness in daily life
2023 accessLevelPublic Public 1.3 MB
Cognitive emotion regulation difficulties increase affective reactivity to daily-life stress in autistic adolescents and young adults
2023 accessLevelPublic Public 190.6 KB
Diurnal cortisol profiles and exposure to stress in adolescents and young adults with 22q11.2 deletion syndrome
2021 accessLevelPublic Public 83.1 KB
All rights reserved by DLCM and the University of GenevaunigeBlack