Dataset of Spirocyclic Amide Acetal Synthesis by [CpRu]-Catalyzed Condensations of α‑Diazo-β-Ketoesters with γ-Lactams

The synthesis of spirocyclic amide acetals (33-93%) has been achieved through Ru(II)-catalyzed condensations of N-carbamate protected pyrrolidinones with metal carbenes derived from α‑diazo-β-ketoesters. Thanks to the mildness of the diazo decomposition conditions induced by a 1:1 combination of [CpRu(MeCN)3][BArF] and 1,10-phenanthroline, the formation of the sensitive products is possible. Full characterization of this carbonyl-ylide mediated process is provided by DFT calculations.

    Organizational unit
    Laboratory of Professor Jérôme Lacour
    Creative Commons Attribution 4.0 International
    Amide, Acetals, Carbonyl, ylide, [CpRu], catalysis, Diazo, decomposition, Spirocycles
Publication date08/07/2021
Retention date17/08/2031
accessLevelPublicAccess levelPublic
duaNoneContract on the use of data
  • Pertschi, Romain orcid
  • Brun, Elodie orcid
  • de Aguirre, Adiran
  • Guénée, Laure
  • Poblador Bahamonde, Amalia orcid
  • Lacour, Jérôme orcid
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