Dataset of Spirocyclic Amide Acetal Synthesis by [CpRu]-Catalyzed Condensations of α‑Diazo-β-Ketoesters with γ-Lactams

The synthesis of spirocyclic amide acetals (33-93%) has been achieved through Ru(II)-catalyzed condensations of N-carbamate protected pyrrolidinones with metal carbenes derived from α‑diazo-β-ketoesters. Thanks to the mildness of the diazo decomposition conditions induced by a 1:1 combination of [CpRu(MeCN)3][BArF] and 1,10-phenanthroline, the formation of the sensitive products is possible. Full characterization of this carbonyl-ylide mediated process is provided by DFT calculations.

Keywords: Amide, Acetals, Carbonyl, ylide, [CpRu], catalysis, Diazo, decomposition, Spirocycles

Publication date

08/07/2021

Retention date17/08/2031

Access levelPublic

SensitivityUndefined

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Laboratory of Professor Jérôme Lacour

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Public 1.6 GB

Laboratory of Professor Jérôme Lacour

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Laboratory of Professor Jérôme Lacour

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Laboratory of Professor Jérôme Lacour

Dataset of Merging polyacenes and cationic helicenes

2019

Public 1.0 GB