Multicentric evaluation of a specific intrathecal anti-Treponema pallidum IgG index as a diagnostic biomarker of neurosyphilis: results from a retro-prospective case-control study

The diagnosis of neurosyphilis (NS) lacks a true “gold standard”, making the diagnosis challenging while consequences of a misdiagnosis are potentially severe. The aim of this multicentric retro-prospective case-control study was to evaluate the diagnostic performance of measuring an antibody index (AI) for the intrathecal synthesis of specific anti-Treponema pallidum (T. pallidum) IgG for the diagnosis of NS.

Organizational unit

Pre Toutous Trellu Research group - Syphilis

Type

Dataset

DOI

10.26037/yareta:io5whhjo2rcibdwpku7v4e5rju

Funding agencies

Swiss National Science Foundation

Keywords

Neurosyphilis, syphilis, diagnostic tool, bacterial infections