Multicentric evaluation of a specific intrathecal anti-Treponema pallidum IgG index as a diagnostic biomarker of neurosyphilis: results from a retro-prospective case-control study

The diagnosis of neurosyphilis (NS) lacks a true “gold standard”, making the diagnosis challenging while consequences of a misdiagnosis are potentially severe. The aim of this multicentric retro-prospective case-control study was to evaluate the diagnostic performance of measuring an antibody index (AI) for the intrathecal synthesis of specific anti-Treponema pallidum (T. pallidum) IgG for the diagnosis of NS. This work has been presented as a poster at the 16th International Society of Neuroimmunology congress in August 2023 in Québec City (Canada) and at the 32nd European Academy of Dermatology and Venereology in October 2023 in Berlin (Germany) and as an oral presentation at the Annual Meeting of the Swiss Society of Dermatology and Venereology in September 2023 in Lausanne (Switzerland).

Organizational unit

Pre Toutous Trellu Research group - Syphilis

Type

Dataset

DOI

10.26037/yareta:io5whhjo2rcibdwpku7v4e5rju

Referenced by the following DOI

• 10.1136/sextrans-2023-055913

Funding agencies

Swiss National Science Foundation

Keywords

Neurosyphilis, syphilis, diagnostic tool, bacterial infections