Multicentric evaluation of a specific intrathecal anti-Treponema pallidum IgG index as a diagnostic biomarker of neurosyphilis: results from a retro-prospective case-control study

    
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            <datacite:creatorName nameType="Personal">Toutous Trellu, Laurence Marie</datacite:creatorName>
            <datacite:givenName>Laurence Marie</datacite:givenName>
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        <datacite:title>Multicentric evaluation of a specific intrathecal anti-Treponema pallidum IgG index as a diagnostic biomarker of neurosyphilis: results from a retro-prospective case-control study</datacite:title>
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    <datacite:publisher>Université de Genève, Yareta</datacite:publisher>
    <datacite:publicationYear>2024</datacite:publicationYear>
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        <datacite:subject subjectScheme="keywords" xml:lang="en">Neurosyphilis;syphilis;diagnostic tool;bacterial infections</datacite:subject>
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            <datacite:contributorName nameType="Organizational">[7315c3fb-42ca-44c6-adb3-9808a85f1f1e] Pre Toutous Trellu Research group - Syphilis</datacite:contributorName>
            <datacite:affiliation xsi:type="datacite:affiliation" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">[UNIGE-Medecine] Université de Genève - Faculté de Médecine</datacite:affiliation>
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            <datacite:contributorName nameType="Personal">LAMBENG, Nathalie</datacite:contributorName>
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            <datacite:contributorName nameType="Personal">Toutous Trellu, Laurence Marie</datacite:contributorName>
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        <datacite:date dateType="Issued">2024-03-26T00:00:00Z</datacite:date>
        <datacite:date dateType="Collected">2007-07-01T00:00:00Z/2022-12-31T00:00:00Z</datacite:date>
        <datacite:date dateType="Created">2024-03-26T13:47:12.303222Z</datacite:date>
        <datacite:date dateType="Updated">2025-04-07T07:35:04.399201Z</datacite:date>
        <datacite:date dateType="Accepted">2024-04-09T09:33:15.848704246Z</datacite:date>
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        <datacite:relatedIdentifier relatedIdentifierType="DOI" relationType="IsReferencedBy">10.1136/sextrans-2023-055913</datacite:relatedIdentifier>
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        <datacite:description descriptionType="Abstract" xml:lang="en">The diagnosis of neurosyphilis (NS) lacks a true “gold standard”, making the diagnosis challenging while consequences of a misdiagnosis are potentially severe. The aim of this multicentric retro-prospective case-control study was to evaluate the diagnostic performance of measuring an antibody index (AI) for the intrathecal synthesis of specific anti-Treponema pallidum (T. pallidum) IgG for the diagnosis of NS.
This work has been presented as a poster at the 16th International Society of Neuroimmunology congress in August 2023 in Québec City (Canada) and at the 32nd European Academy of Dermatology and Venereology in October 2023 in Berlin
(Germany) and as an oral presentation at the Annual Meeting of the Swiss Society of Dermatology and Venereology in September 2023 in Lausanne (Switzerland).</datacite:description>
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            <datacite:funderName>[SNF] Swiss National Science Foundation</datacite:funderName>
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