Multicentric evaluation of a specific intrathecal anti-Treponema pallidum IgG index as a diagnostic biomarker of neurosyphilis: results from a retro-prospective case-control study

The diagnosis of neurosyphilis (NS) lacks a true “gold standard”, making the diagnosis challenging while consequences of a misdiagnosis are potentially severe. The aim of this multicentric retro-prospective case-control study was to evaluate the diagnostic performance of measuring an antibody index (AI) for the intrathecal synthesis of specific anti-Treponema pallidum (T. pallidum) IgG for the diagnosis of NS.

    Organizational unit
    Pre Toutous Trellu Research group - Syphilis
    Type
    Dataset
    DOI
    10.26037/yareta:io5whhjo2rcibdwpku7v4e5rju
    Funding agencies
    Swiss National Science Foundation
    Keywords
    Neurosyphilis, syphilis, diagnostic tool, bacterial infections
Publication date26/03/2024
Retention date24/03/2034
accessLevelRestrictedAccess levelRestricted
SensitivityGreen
duaNoneContract on the use of data
None
Contributors
  • Alberto, Chloé
  • LAMBENG, Nathalie
  • Deffert, Christine
  • Bréville, Gautier
  • GAYET-AGERON, Angèle orcid
  • Lalive, Patrice
  • Calmy, Alexandra
  • Coste, Alix
  • Papadimitriou-Olivgeris, Matthaios
  • Braun, Dominique
  • Lienhard, Reto
  • Bosshard, Philipp
  • Fontao, Lionel
  • Toutous Trellu, Laurence Marie orcid
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