Mitochondrial copy number variation as a surrogate marker of acquired resistance to the bifunctional electrophilic chemotherapeutic drug busulfan

Experimental data obtained that was used to prepare the report. The study used MOLM13 cells. cells were exposed to Busulfan and also to cytarabine to develop acquired resistance, and was correlated with that of dynamic changes observed in mitochondrial copy number. lymphoblastoid cells (LCLs) were also used as normal cells to test the impact of mitochondrial copy number in relation to the cellular sensitivities to busulfan.

    Organizational unit
    CANSEARCH Research Platform for Pediatric Oncology and Hematology
    Type
    Dataset
    DOI
    10.26037/yareta:dvmtwmu6y5eafp7oz6q7wnac7u
    License
    Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
    Keywords
    data, mitochondrial copy number, AML, busulfan, cytarabine, resistance, IC50, real-time PCR
Publication date24/08/2022
Retention date21/08/2032
accessLevelPublicAccess levelPublic
SensitivityBlue
duaNoneContract on the use of data
Contributors
  • Uppugunduri Satyanarayana, Chakradhara Rao orcid
  • Boudal-Khosbheen, Mary
  • Sarmiento, Yoann
  • Marino, Denis
  • Mlakar, Vid
  • Nava, Tiago
  • Ansari, Marc
  • Jurkovic Mlakar, Simona
29
5
  • Quality (0 Reviews)
  • Usefulness (0 Reviews)

Datacite metadata

Packages information

Similar archives

CANSEARCH Research Platform for Pediatric Oncology and Hematology
Molecular Dynamics simulation between human UGT2B10 and putative ligands used in pediatric busulfan-based conditioning regimens prior to hematopoietic stem cell transplantation (HSCT)
2022 accessLevelPublic Public 316.8 GB
All rights reserved by DLCM and the University of GenevaunigeBlack